The objective of the Women and Infants' Health Specimen Consortium (WIHSC) is to facilitate patient-related research within the Washington University academic community of clinically important issues related to pediatric diseases, maternal-fetal interaction and pregnancy, Tissue samples from serum to amniotic fluid and placenta will be collected from patients and linked with a clinical database. The unique aspect of this Consortium is that individual mother-infant pairs are followed pre-pregnancy, during pregnancy and post-partum during the neonatal period and beyond. Data will be collected throughout gestation and infant and pregnancy outcomes can be directly examined in the context of the data obtained. Five original hypothesis driven projects were used to start the consortium and three more projects directly related to the aims of the CDI were added for this Large Initiative Grant. These three include: 1) intrauterine growth retardation and metabolomic profiles; 2) Inborn errors of metabolism and pregnancy; and 3) Assisted reproductive technologies and neonatal outcomes. Samples collected by this consortium would be available to these projects as well as to investigators within the CDI community performing studies in any of the CDI Center themes-Heart Disease, Cancer, Pulmonary Disease, or Musculoskeletal/Metabolic Disease. This Consortium, the WIHSC, has the potential to become a vital source of tissue and patient data, both mother and child, needed to accelerate new pathways to discovery in childhood disease.